Regulatory cells in the skin: Pathophysiologic role and potential targets for anti-inflammatory therapies
皮肤中的调节细胞：抗炎治疗的病理生理学作用和潜在靶点
摘要：
Inflammation is a fundamental defense mechanism to protect the body from danger, which becomes potentially harmful if it turns chronic. Therapeutic strategies aimed at specifically blocking proinflammatory signals, particularly cytokines, such as IL-4, IL-6, IL-13, IL-17A, or TNF-α, have substantially improved our ability to effectively and safely treat chronic inflammatory diseases. Much less effort has been made to better understand the role of potential anti-inflammatory mechanisms. Here we summarize the current understanding of regulatory cellpopulations in the context of chronic inflammation, namely macrophages, Langerhans cells, myeloid-derived suppressor cells, and regulatoryT and B lymphocytes. Emphasis is given to the skin because many different immune-related diseases occur in the skin. Development, phenotype, function, and evidence for their role in animal models of inflammation, as well as in the corresponding human diseases, are described. Finally, the feasibility of using regulatory cells as targets for potentially disease-modifying therapeutic strategies is discussed.
炎症是保护身体免受危险的一种基本防御机制，如果它变成慢性，它就会变得有潜在危害。旨在特异性阻断促炎信号的治疗策略，特别是细胞因子，例如IL-4，IL-6，IL-13，IL-17A或TNF-α，已经显着提高了我们有效和安全地治疗慢性炎性疾病的能力。为了更好地理解潜在的抗炎机制的作用，已经做了很少的努力。在这里，我们总结了目前对慢性炎症背景下调节细胞群的理解，即巨噬细胞，朗格汉斯细胞，骨髓衍生的抑制细胞和调节性T和B淋巴细胞。皮肤受到重视，因为皮肤中会出现许多不同的免疫相关疾病。描述了它们在炎症动物模型中以及相应的人类疾病中的作用的发展，表型，功能和证据。最后，讨论了使用调节细胞作为潜在疾病修饰治疗策略的靶标的可行性。
皮肤中的调节细胞：抗炎治疗的病理生理学作用和潜在靶点
摘要：
Inflammation is a fundamental defense mechanism to protect the body from danger, which becomes potentially harmful if it turns chronic. Therapeutic strategies aimed at specifically blocking proinflammatory signals, particularly cytokines, such as IL-4, IL-6, IL-13, IL-17A, or TNF-α, have substantially improved our ability to effectively and safely treat chronic inflammatory diseases. Much less effort has been made to better understand the role of potential anti-inflammatory mechanisms. Here we summarize the current understanding of regulatory cellpopulations in the context of chronic inflammation, namely macrophages, Langerhans cells, myeloid-derived suppressor cells, and regulatoryT and B lymphocytes. Emphasis is given to the skin because many different immune-related diseases occur in the skin. Development, phenotype, function, and evidence for their role in animal models of inflammation, as well as in the corresponding human diseases, are described. Finally, the feasibility of using regulatory cells as targets for potentially disease-modifying therapeutic strategies is discussed.
炎症是保护身体免受危险的一种基本防御机制，如果它变成慢性，它就会变得有潜在危害。旨在特异性阻断促炎信号的治疗策略，特别是细胞因子，例如IL-4，IL-6，IL-13，IL-17A或TNF-α，已经显着提高了我们有效和安全地治疗慢性炎性疾病的能力。为了更好地理解潜在的抗炎机制的作用，已经做了很少的努力。在这里，我们总结了目前对慢性炎症背景下调节细胞群的理解，即巨噬细胞，朗格汉斯细胞，骨髓衍生的抑制细胞和调节性T和B淋巴细胞。皮肤受到重视，因为皮肤中会出现许多不同的免疫相关疾病。描述了它们在炎症动物模型中以及相应的人类疾病中的作用的发展，表型，功能和证据。最后，讨论了使用调节细胞作为潜在疾病修饰治疗策略的靶标的可行性。
